Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release

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Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release

AIMS Animal models have been developed that allow simulation of post-traumatic joint contracture. One such model involves contracture-forming surgery followed by surgical capsular release. This model allows testing of antifibrotic agents, such as rosiglitazone. METHODS A total of 20 rabbits underwent contracture-forming surgery. Eight weeks later, the animals underwent a surgical capsular rel...

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Surgical Release of Severe Flexion Contracture for Oncologic Knee Arthroplasty

BACKGROUND Severe postoperative knee contractures after arthroplasty or megaprosthesis reconstruction occur rarely, but are devastating complications. Management of preoperative flexion contractures is well-described, but there is a paucity of literature for surgical treatment of postoperative contractures. A retrospective chart review was performed for a single surgeon of cases between 1996 an...

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Effectiveness of Methylene Blue in the Prevention of Stifle Joint Arthrofibrosis in Rabbit Models

Background: One of the major challenges in orthopedic surgery is the prevention of arthrofibrosis, which can besuccessfully alleviated in its early stages. Many studies suggest the administration of methylene blue (MB) as anaccessible and effective agent for the prevention of post-operation adhesions. The purpose of this study was to evaluatethe efficacy of MB in the preventio...

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ژورنال

عنوان ژورنال: Bone & Joint Research

سال: 2016

ISSN: 2046-3758

DOI: 10.1302/2046-3758.51.2000593